Drug Resistant Bacteria / Virus Threat

Recent news stories are creating fear about the drug resistant bacteria and viruses which are wreaking havoc with national health. I do not want to diminish the real problems this causes for some people but rather hold out hope that solutions exist and are readily available – plant based options. Especially moringa powder with it’s many benefits.

Moringa contains a great many cytokinins, the class of chemicals which control the seasonal development and life cycle of plants. Similar chemicals exist in the human body and control and influence our immune systems.

There is not sufficient space hear to do justice to the subject, suffice to say that Monica Marcu, Pharm.D., Ph.D., develops this knowledge in her book, Moringa, An Introduction (ISBN 978-193305771-2).

I have included a link to a great article on her work.

Hope you find this helpful and hopeful!

The old saying is an ounce of prevention is worth a pound of cure. The metric equivalent, a gram of prevention is worth a kilo of cure, increases the benefits of prevention many fold!

Does it make sense to treat illness with a single chemical option which bacteria and viruses can adapt to, or use a complex of chemicals which acts in synergistic fashion to empower our immune systems and/or treat illnesses? What do you think? The complex of chemicals is readily available from plant based sources and may act in a synergistic fashion with existing treatment options.

My studies on multi-drug resistant malaria have revealed that there is a glyco-protein pump which regulates the internal atmosphere of the bacteria. This same pump recognizes the drug which could kill it, and subsequently excretes it. On a hopeful note, this glyco-protein pump can be shut down with a bioflavinoid complex – available in moringa! Could this be the answer to drug resistance?

In summary, I believe there are two fronts on which to fight disease. One, enlivening our immune systems with moringa powder – this represents no potential for negative drug interaction. The other front is the use of moringa powder in conjunction with current treatment options, potentially resulting better outcomes for two reasons – an improvement in the functioning of the persons immune system as well as the potential shutting down of the disease organisms defense system.

The writers accepts no responsibility for negative consequences, real or imagined, from the implementation of this concept. Please consult a medical professional.

Kind Regards, Tim

Cultural Perspective on Plant Based Medicine

Moringa trees thrive in arid Haiti

image (3)

The photo above shows the moringa trees planted in early May, 2014 as they thrive against all odds in the hostile Haitian climate.

These trees, when they are mature, will produce a strain of seeds which contain a tendency toward drought resistance. Successive generations of plants produced under the same conditions with the seed from the aforementioned trees, will create an excellent strain for direct seeding on the hillside gardens where irrigation is not available.

Another Haitian success story!!

Many thanks to Touch Marketing for making this good news story available.

Kind Regards,

Tim

Ebola and Plant based Treatment Options

I am constantly amazed at the medical communities objective in light of new outbreaks of diseases which have plagued man kind for millenia – let’s develop a vaccine.

Vaccines have yielded huge benefits to the human race, don’t get me wrong. However, people who live in remote areas and cannot access such treatment, need options. These people would benefit from not being subject to the weak link of supply chains, which ever malady they may have.

When I ponder such diseases as malaria with literally billions of cases annually, pills do not cut it for poor people. One set back in the move toward plant based solutions is pill sellers. Wealth creation has its roots in a healthy population. Pill sellers like their business. And it’s profits. But how much more could they make if the population was well and able to work to capacity? I venture to say they could make more selling windows, doors and construction materials. These are legitimate businesses in which pill sellers could participate.

Papaya leaves as medicineTake a boo at this article on papaya – one of my favorites for staying healthy in the tropics. It treats or prevents two of the 4 big killers – malaria and dysentery. I am walking proof that it works!!

Photo to follow!!!

http://papayaleaves.wordpress.com/page/2/

Kind Regards, Tim

Have a marvelous tropical holiday, topped off with a cup of papaya leaf tea daily!! Do some research to see if this product is suited to you!!

My condolences to those who have lost loved ones to the ebola outbreak.

Great News from Haiti

Wow, it’s been a while!! About a month ago I got home from an exhilarating trip to Haiti where we started hillside terracing for tree based agriculture – specifically moringa trees. This due to the many benefits of same. These trees will be used by Children’s Lifeline in their feeding program and to develop an export business of dried leaves.

The great news is that the rains have been regular since I left and the trees are thriving. I planted about 500 seeds which will yield a good number of trees.

Terracing in tropical, hilly places is a very powerful way to conserve rainfall and redevelop the ground water resources. The rain water, which would normally just flow off the hill causing erosion, is collected in trenches which are specially designed to follow the contours of the hill, which means the water can pool and generally finds its way into the soil. Particularly in Haiti where the soils are sandy and light.

Erosion is the number one agricultural problem in the world.

Wanted to share this great news! On another note, my Ugandan friend and his family are living in a banana fiber house, which is a bummer. I have contacted Habitat to see if they can help. Any ideas out there for a way to help them get better accommodation?

Cheers, Tim

Papaya Leaf Study from Kampala, Uganda

Several years ago I was able to get this study done at the Makerere University in Kampala, Uganda. Hope you find it good bed time reading!! The tables do not translate into the blog but the other text is fine. Please let me know what you think.
papaya leaves for medical use
Preliminary Report

ACUTE PRECLINICAL SAFETY STUDY of the CARICA PAPAYA LEAVES USED AS MALARIA PREVENTITIVE IN WESTERN UGANDA

INTRODUCTION
The role of plant/herbal medicines in the treatment and prevention of diseases is regaining its place in community health care. In Uganda a number of plants are currently used in the communities to treat and prevent diseases. One such plant medicine is the Carica papaya (pawpaw) leaves boiled and drunk every week to prevent malaria. The effectiveness of such medicines remains unknown due to lack of scientific evidence.

AIM
In this study the safety profile i.e. acute toxicity and sub chronic toxicity of the Carica papaya leaves was investigated using the WHO recommended laboratory animal test models and procedures. The findings in this study are useful guide for the clinical studies that may be conducted.

METHODS
Preparation of the Extract.

The freshly harvested leaves of Carica papaya were weighed, chopped, and extracted in ethanol-acetic acid (90%+10%) solvent mixture by cold soaking for 5 days and filtered (This solvent mixture gives the highest yield of alkaloids and other active principles and also its polarity is closest to that of water a solvent used in the communities). The marc was discarded and the filtrate concentrated in an oven temperature of 50 degrees C to solid state. Known weights of the solid extracts were suspended in distilled water and the filtrates obtained. The filtrate was spanned at 3500 rev/min for five seconds and a clear supernatant obtained. The concentration of the supernatant was obtained by subtracting the total weight of the dry filter (residue) from the original extract weight suspended.

Single Dose / Acute Toxicity profile.

This test in addition to providing the degree of lethality of the medicine/extract also provides useful pharmacological and clinical effects resulting from doses administered by the oral route and one other route in lethal dose range to the test models. The test also aids the estimation of the median lethal dose, which is very useful in classification of the test substance based on its toxicity.

The median lethal dose therefore was determined by first obtaining the approximate median lethal doses for the intra-peritoneal (IP) and oral (PO) routes. Ten pairs of mice were administered doses 500mg/kg, 1500mg/kg, 2000mg/kg and 2500mg/kg by the ip route. Another set of 10 mice in pairs received by the oral route doses 1500mg/kg, 2500mg/kg, 5000mg/kg, 7500mg/kg and 1000mg/kg. The mice had been fasted for 18 hours. The mice were observed for 48 hours and the oral and IP dose that killed 50% of the mice gave the approximate median lethal doses (LD50). The IP route showed approximate LD50 at 1000mg/kg while the oral route gave two points 2500mg/kg and 7500mg/kg. A repeat of the oral dose gave more variations suggesting variable bioavailability due to possible variation in first pass effect following oral administration of the extract. Such various are observed when acetylcholine like alkaloids is administered to rodents by the oral route. A repeat of the IP dosing twice showed consistency in the observed effects.

The actual IP median dose was determined using doses chosen in such a way that five dose levels were used, one dose equivalent to the approximate median lethal dose by the oral route, two doses below and two doses above it. The doses used were 500mg/kg, 700mg/kg, 1000mg/kg, 1200mg/kg and 1500mg/kg. These doses were administered to five groups of six mice each while the sixth group of six mice received equivalent volume of distilled water. The median lethal dose was then determined by both the graphical and arithmetic methods described in fundamentals of experimental pharmacology by Ghosh(1984)

Repeated dose toxicity/ sub chronic Toxicity
This test provides toxicities and side effects that may arise from long-term use of a drug. Effects on major organs such as liver, kidneys, skin, bone marrow etc are studied.

In this study multiple or repeat dose effects were assessed by administering daily oral doses equivalent to 1%, 10% and 25% of the IP LD50 (843mg/kg) to young growing male rats aged 6 weeks for three weeks. Male rats (24) from the faculty of veterinary medicine Makerere University were purchased were acclimatised in the study laboratory for 1 week and were fed on standard diet (mice pencil).
On the study day, the rats were randomly divided into four groups of six each. The average group weight was determined and recorded. C. papaya leaf extract was prepared and administered in doses 8.4mg/kg, 84.3mg/kg and 210mg/kg to groups I, II and III respectively. Group IV the control group received daily equivalent volume of water. The weights of the animals were determined every third day and recorded. Other observations were recorded on the daily basis. At the end of the dosing phase the animals were anesthetized with chloroform and blood equivalent to 4 mls drawn from the venacava. The blood was sent for clinical chemistry and hematology. The animals died soon after all the blood was drawn. The major organs were weighed and together with the whole animal were sent to a veterinary pathologist for autopsy.

RESULTS
Approximate IP Median Lethal Dose Determination in Mice

Dose(mg/kg)
500
1000
1500
2000
2500
No. per group
2
2
2
2
2
No. dead
0
1
2
2
2

Approximate IP Median Lethal Dose in Mice = 1000mg/kg

Approximate Oral Median Lethal Dose Determination in Mice
Dose (mg/kg)
1500
2500
5000
7500
10000
No. per group
2
2
2
2
2
No. dead
0
1
0
1
2

Approximate Oral Median Lethal Dose in Mice was highly variable indicating possible variation in oral bioavailability of the active components.

Actual IP Median Lethal Dose Determination.
Group
Dose(mg/kg)
InDose
Dead/Total
Dead%
Corrected%
Probit
I
500
2.7
1 of 6
16.7
16.7
4.05
II
700
2.8
2 of 6
33.3
33.3
4.56
III
1000
3
3 of 6
50
50
5
IV
1300
3.11
5 of 6
83.3
83.3
5.95
V
1500
3.18
6 of 6
100
95.8
6.75
VI
0.00(control)

0 of 6
0

Corrected formula: For the 0% dead: 100(0.25/n)

For the 100% dead: 100((n-0.25)/n) Where n is the number of animals in the group.

LD50 DETERMINATION BY GRAPHICAL METHOD

P
r
o 8
b 6
i 4
t 2
s 0 ____________________________________________________________________
2.6 2.7 2.8 2.9 3 3.1 3.2 3.3
Log (dose)

Actual oral Median Lethal Dose by Graphical Method.

From the graph probit 5.0 corresponds to log Dose equal to 2.92

Antilog (2.92) = Median Lethal Dose = 831.76 mg/kg.

Standard error of LD50 = (LogLD84-LogLD16)/ √2N
(3.09-2.68)/ √12 = 0.41/3.46 = 0.12

Actual Median lethal dose by the arithmetic method described by Karber.

Group
Dose (mg/kg)
No. of Mice
Dose diff- erence (a)
Dead
Mean Mort- ality (b)
Product (axb)
1
500
6

1


2
700
6
200
2
1.5
300
3
1000
6
300
3
2.5
750
4
1300
6
300
5
4
1200
5
1500
6
200
6
5.5
1100

3350

LD50 = 1500-(3350/6) = 1500 – 558.33 = 941.67mg/kg.

The two methods show that the median lethal dose, which is a measure of acute toxicity / single dose toxicity, lies between 800mg/kg to 1000mg/kg for the IP route.

The approximate oral bioavailability of the extract in mice is 2.5. The estimated oral median lethal is above 2500mg/kg.

Summary of Observations in mice following Acute Dose.
Inactivity/behaviour of the mice
Oral doses
Intraperitonial doses
1. Photophobia

2. Feeding

3. Aggressiveness

4. Respiration

5. Piloerection

6. Lacrimatiom

7. Diarrhoea

8. Urination

9. Convulsions
1. -Dose dependent

2. -↓sed & dose dependent

3. – none

4.-↑sed & dose dependent

5. None

6.- Marked and not dose dependent
7.- None

8. -Marked & not dose dependent
9. -Mild & not dose dependent
1. – Dose dependent

2.-same as oral

3.-same as oral

4.- same as oral

5.- same as oral

6. None

7. Same as oral

8. None

9. Same as oral

-At Doses greater 5000mg/kg by oral route, the effects occurred within 15-30 minutes while at lower doses the effects delayed by up to 5 hours.
-The effects were prolonged; some up to 10 hours indicating the drug probably has a long half-life/duration in the body.

-For intraperitoneal (IP) route, doses greater 500 mg/kg gave immediate effect.

-IP doses greater than 1000mg/kg were lethal within 30 to 60 minutes of administration.

-A unique difference noted was the diuretic (water and salt loss via urine) and diaphoretic (water and salt loss via sweat) effects by the oral route, which did not occur following the IP route doses. This could imply that the extract active ingredients under biotranformation when given by the oral route into active metabolite(s) with diuretic activities.

Growth Suppression Effects in Rat Models
Time(days)
I
II
III
IV

93.0±10.9
96.0±9.0
86.6±11.9
93.5±9.9

108.6±9.5
109.6±9.3
94.1±8.7
113.03±12.3

106.6±8.4
109.3±14.4
97.0±8.7
105.8±9.5

125.0±8.6
121.3v15.8
107.0±12.5
126.7±9.7

131.9±8.6
132.0±13.7
101.5±9.6
141.8±9.8

130.5±8.6
143.0±15.3
107.0±7.1
152.0±10.5

146.0±8.5
148.1±15.6
110.4±6.6
157.3±11.7

155.9±7.3
157.6±17.8
115.4±7.9
167.7±12.5

Series=1=gpI, 2=gp II, 3=gp III, 4=gp IV

(A chart of the above results which is presented by the report writers, is not in this presentation.)

The drug suppresses growth significantly at IP doses greater than 200mg/kg administered on daily basis.

Haematology and Clinical chemistry Results for Selected Parameters in The Rat Models

I
II
III
IIII
Haemoglobin
(g/dl)
13.47±0.05
13.53±0.83
13.4±0.87
13.13±3.53
WBC (cells/mm cubed)
4600±400
4466±416
4600±600
4733±305
N (%)
59.0±1.4
66.0±4.0
63.33±4.16
64.67±5.03
L (%)
41.0±1.4
34.0±4.0
36.67±4.16
35.33±5.03
LFT – GOT
– GPT
7.33±1.55
5.0±1.0
9.0±1.0
7.67±0.58
7.67±1.53
6.0±1.0
7.67±1.53
5.67±2.08
RFT – creatine(mg/dl)
0.73±0.15
0.57±0.21
0.47±0.31
0.47±0.23

The drug had little effect on the major drug handling organs even at doses that suppress growth. All the parameters measured were within the normal/physiological ranges.

Observed Rat behaviour following repeated drug dosing compared to the control group.

– Overall the animals did not show significant behavioural changes.
Three animals died. 1 rat in group II and 2 rats in group III developed diarrhoea and lower abdominal tenderness and died. These deaths were not associated with the drug.
None of the animals developed injection necrosis.
All animals in group II and III lost weight; group III had marked weight loss.

Autopsy Results: pending from the pathologist.

Recommendations.

1. The C. Papaya leaf oral median lethal dose is greater than 2000mg/kg. According to the World Health Organisation and the European Union, a herbal drug with median dose above 2000mg/kg is very safe for human use.
2. C. Papaya leaf extract taken daily in oral doses less than 200 x 2.5mg/kg or 0.5g/kg may not be toxic in human beings. i.e. up to 350g = or 8 average leaves decoction consumed daily by an adult should be safe.
3. C. Papaya taken in high doses daily may cause hypotension and electrolyte imbalance in the users.
4. C. papaya taken once a week as herbal tea against malaria should be safe but this claim should be verified by clinical investigations.

Ogwang P. Engeu 1, Tumusiime Ralph 1, Agwaya Moses 1 & Galiwago Budra 2.

1. Natural Chemotherapeutic Research Laboratory – Ministry of Health Kampala, PO Box 4864 Kampala.
2. Faculty of Veterinary medicine, Makerere University, PO Box 7062, Kampala.

One of my Favorite Trees – Papaya

Hey Plant based treatment friends,
Take at look at this informative video.

Benefits of Papaya Leaf extract / tea

Enjoy and hope you find better health as a result. “Health is for all, not only those with money”. Tim Wise, March 7,2014

Haiti Agricultural Program

Wow, two weeks have flashed by and the agricultural (ag) program at Mission Lifeline in Arachaie, Haiti has begun.

Adam and Jordani are the two capable Haitian men who will care for the gardens – both natural men of the soil who love plants and feel responsible for the project and its outcome.

The clearing of the land, rounding up the stones, subduing those small cactus plants with the barbed thorns, cutting back the euphorbia curalis trees which we named burning milk trees because the copious quantity of milky sap they ooze when cut or bent burns ones skin, and the sweating by the bucketful, were all part of the experience. The result was about half an acre of fertile land that will yield well with the addition of a little seed, water, mulch and local fertilizer ie well rotted manure. With temperatures in the mid thirties, the photo below shows the dramatic results of moringa seedlings started at the garden. Moringa is the second fastest growing tree in the world and provides a complete compliment of amino acids and vitamin C – a complete diet in one simple package!!

Mission Lifeline has done a tremendous job of developing personnel who are on time at the airport, understand our needs as guests, cook the most amazing food and kept our accommodation clean and tidy. The facilities were second to none, with beautiful tiled rooms and showers, ensuite kitchenette, screened windows for insect control and full laundry services.

The cultural angle included roosters crowing and dogs barking in the wee hours and the ladies from the kitchen who gather for prayer and worship at 4.30am prior to starting work at 5, Monday through Friday. Early to bed, greeting the sunrise and taking a siesta seemed to work well.

At our closing meeting, we determined that the risk factor to the garden was the persistent goats. Grazing animals represent a considerable deterant to agricultural development in many countries. Let’s hope the thorny fences hold up well.!

Off to Haiti!!

The time has come to put to practice the hard won knowledge of moringa and other tropical agricultural interventions.

On January 28, my friend Chester Venhuisen and I will depart Pearson airport for Haiti, where we will work with Children’s Lifeline in Arcahaie (about 1 hours drive north of Porte au Prince). The mission has one couple from the USA on site, employs over 150 people from the surrounding area and feeds 3,000 children per day. Our mission, should we choose to accept it (which we have!!), is to create an agricultural program. This program will produce food for the mission as well as teach the local people how to use moringa and a variety of other crops to improve their own health outcomes. Very exciting for people like myself with a green thumb and passion for improving people lives. We will be introducing the concept of tree based agriculture as a component in food security. Trees can be used to create micro climates where more tender vegetable crops can thrive.

I was reading some technical notes about moringa today which say that under intense culture, moringa can produce 650 tons of vegetables per hectare. Is global hunger really necessary? Considering that people can and like to use this this veggie as a dried additive to soups and stews. I would say there a lot of moringa powder benefits , which is why I own moringapowderbenefits.ca.

We will also be promoting the use of vetiver grass for erosion control, contouring hillsides, mulching and soil reclamation. There are great youtube videos on this subject.

There is also a construction education component in which we will be teaching the building trades. Such as carpentry, masonry, concrete work and other construction techniques.

Keep an eye open for my online sales of moringa powder, a product of Haiti. This will be a product which gives twice – benefits your health and the Haitian economy. Is this the new model for global development?


Thanks for your support of this venture. Keep an eye on my blogs!! Which will be available, technology permitting!!

Happy New Year

Hi fellow interneters,

Hope 2013 was a great year and that 2014 is even better. I am looking forward to enjoying good health, DV, using moringa powder to boost my immune system and provide excellent dietary supplimentation. Plus neem leaf powder to fend off the flu and common cold when they come a knocking at my door. I have successfully fended off a cold and flu in the last 2 months of 2013 using neem leaf powder. I make a cup of very bitter tea using a rounded teaspoon of the neem leaf powder, add the boiling water, let it steep until the temperature is drinkable, then down the whole thing, leaves and all.

Neem Tree

A note to those who are in the family way – neem is an effective birth control product so be careful. In fact it can cause abortions and makes men temporarily sterile. This could be good and it could be bad depending what you want.

Look forward to your feedback on what you would like to know about neem or moringa powder benefits. Happy New Year and Happy reading as you improve your health outcomes using an approach that works for you.

Kind Regards,

Tim Wise

Moringa is GREAT, but…

… it is difficult to get the powder to dissolve in water, sometimes. I recently got a batch from nuts.com which seems to be mixing just fine.
However, for every problem there is a solution. Check out this video on how to make a moringa smoothie. Looks delicious.
I am not promoting the company or its products, just thought the video was excellent.

Enjoy and hope you have a healthy day!!

Tim,
PS – look forward to hearing back from you, particularly in the near future when I launch my own line of moringa products which will be BAM – business and missions. I will be combining my international development/food security interests with the opportunity to offer health giving products. Because moringa powder benefits are many and yours truly is getting them!!

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