When we decide to explore plant based medicine, safety is the number one consideration. Mission critical is do no harm.
Many years ago, while working in Uganda, a friend with connections agreed with this hypothesis. He commissioned a scientific study to determine the LD50 of papaya.
LD50 is the lethal dose which kills 50% of the subjects. This test is performed using laboratory rodents. Not very nice but progress is costly.
Following are the results and recommendations. Please consider this scientific evidence as you consider recommending papaya for your patients. I believe they will thank you. I have benefited big time from this. I eat a 3-4 inch square of fresh leaf daily while in the tropics. My stomach is very strong as a result!! No missed days of work or missed nights sleep for emergency visits. No staying close to the washroom. No smooth muscle relaxants. Just smooth sailing!!
The link below goes to an LD50 study done at the Makerere University in Kampala, Uganda